Work Packages

WP1: Mental Health Epidemiology & Interventions


  1. To provide high-quality data to the evidence base of the prevalence and severity of rapidly changing mental health needs across Europe in the general population, taking into consideration demographic and vulnerability factors such as age (younger and older age), education socio-economic status level (poverty and unemployment) and migrant status.
  2. To identify and aggregate information about published interventions that have addressed (a) sub-clinical mental health symptoms and (b) mental disorders with a focus on the identified vulnerable populations.
  3. To select from these, the most promising interventions to be included in COMBINA and the MENTINA app. These interventions must collectively address (a) the specified vulnerable groups, (b) mental disorders (depression, anxiety disorders, suicide prevention) and/or (c) sub-clinical mental health challenges (e.g. subthreshold depressive syndromes, mental distress, resilience building).
  4. To address the existing knowledge gap on mental health data in South-east Europe.

WP2: COMBINA Development


  1. To create COMBINA by using the results (data and interventions) identified to extend and adapt the EAAD 4-level programme for sub-clinical mental disorders and specific vulnerable groups.
  2. To develop the Intervention materials and the associated Implementation Handbook: A new community-based intervention model, focused on vulnerable groups and sub-clinical mental health challenges to enable implementation of COMBINA in each of the five regions (IMIM: Spain, NSRF: Ireland, ERSI: Estonia, SEERC: Greece, and CCHW: Albania).
  3. To optimise and refine COMBINA after the 24-month study, integrating feedback and results from the implementation (WP3) and evaluation (WP4).


This WP carries out a 24-month validation of the COMBINA programme.


  1. To establish the regional alliances for mental health in the five intervention regions.
  2. To secure ethical approval in each region.
  3. To ensure the collection of the evaluation data at each time point by cooperating with the local partners in the five intervention and the five control regions, in close cooperation with WP4.
  4. To ensure the COMBINA intervention programme is accessible to the target population, including vulnerable groups, in the intervention regions via translation and local adaptation.
  5. To implement the COMBINA intervention programme in the five intervention regions.
MENTBEST - Work Packages

WP4: COMBINA Evaluation

The evaluation of COMBINA will

  • assess the effectiveness of the newly developed interventions (outcome evaluation),
  • examine the cost-effectiveness of the interventions (economic evaluation),
  • and consider the process of implementation (process evaluation).


  1. Identify and deploy the most appropriate evaluation instruments for COMBINA.
  2. Assess the effectiveness of the newly developed interventions (outcome evaluation).
  3. Evaluate the process of implementation (process evaluation).
  4. Examine the cost-effectiveness of the interventions (economic evaluation).
  5. Formulate recommendations on how to improve COMBINA.

WP5: MENTINA Development


  1. To develop the MENTINA app based on MSS’s existing CE-marked digital health platform for people with sub-diagnostic depressive symptoms and/or prior depressive episodes.
  2. To provide and develop a machine learning platform for cooperative data storage, data pre-processing, development and training of predictive models, and their deployment in the MENTINA app.
  3. To provide the MENTINA app for the MENTINA trial (WP6) and the modified version as an intervention element in COMBINA (WP 2,3), and to prepare for medical device approval.
  4. To enhance the MENTINA app, including the addition of personalised feedback based on the intelligence analysis of the individual user’s data.
  5. To use the data collected within the MENTINA trial to optimise the algorithms integrated in the MENTINA app by a systematic comparison of different traditional and AI-enabled approaches to predictive analytics based on complex time series data.

WP6: Trial Delivery & Evaluation


  1. To obtain ethical approval and ensure adherence to GDPR for the MENTINA trial for each of the three trial sites (Denmark: PCC, Germany: GDF and Spain: IMIM).
  2. To evaluate the effect of the MENTINA app on depressive symptoms and distress in a Randomised Control Trial (RCT) across three trial sites involving individuals with a vulnerability concerning depressive syndromes (sub-diagnostic depressive symptoms, earlier depressive episodes).
  3. To use the trial evaluation results to inform the final optimisation of the MENTINA app (WP5).
MENTBEST - Work Packages

WP7: Participatory Action Approach


  1. To establish a representative sample of stakeholders who will be the end-users of COMBINA and the MENTINA app, plus experts in social sciences, and recruit them as co-creators of these interventions.
  2. To seek and incorporate comprehensive co-creator inputs to all WPs, regarding the priorities, preferences, requirements and experiences of vulnerable individuals, patients, healthcare providers, policy-makers and community stakeholders.
  3. To engage co-creators as an integral part of the research and leadership teams to provide unique perspectives in the planning, delivery, analysis and synthesis of the whole research process including publications authorship.

WP8: Communication, Dissemination & Future Implementation

Activities in WP8 will be led by the WHO Collaborating Centre at the UAM, in close collaboration with the other MENTBEST partners.


  1. To formulate a communication and dissemination plan to increase the awareness in diverse stakeholder communities about the aims of the MENTBEST project and various activities that will be undertaken as part of the project, from the outset of the project.
  2. To raise awareness in diverse stakeholder communities about the aims of MENTBEST and disseminate key research findings related to all work-packages to a wide range of audiences including end-users, service providers, ministries of health, education and labour, policy-makers at the regional and local level, mental health professionals and mental health researchers, insurance companies and funding bodies, among others.
  3. To collaborate closely with other projects in networking and joint activities.
  4. To develop and distribute to policy-relevant stakeholders a policy brief setting out policy recommendations to facilitate the uptake of tools developed and evaluated within the MENTBEST project.
  5. To promote the availability of the enhanced COMBINA, supporting further regions and/or countries to progress implementation (with the support of EAAD), post-project.
  6. To develop an exploitation model for COMBINA.

WP9: Project Management

WP9 supports the effective integration, management and delivery of MENTBEST WPs.


  1. To coordinate all project activities and ensure that partners work together effectively.
  2. To facilitate scientific and research development, and the success of the project through monitoring of progress, management of resources, open communication and coordination of activities.
  3. To integrate the multidisciplinary perspectives and facilitate effective collaboration.
  4. To ensure the project meets its contractual commitments as per the Grant Agreement.
  5. To predict, mitigate and overcome research-related risk.
  6. To maximise the impact and broader value of the project, both during and beyond.